Rewrite <math><mstyle displaystyle="true"><mn>16</mn><msup><mrow><mi>x</mi></mrow><mrow><mn>4</mn></mrow></msup></mstyle></math> as <math><mstyle displaystyle="true"><msup><mrow><mo>(</mo><mn>4</mn><msup><mrow><mi>x</mi></mrow><mrow><mn>2</mn></mrow></msup><mo>)</mo></mrow><mrow><mn>2</mn></mrow></msup></mstyle></math> .

Rewrite <math><mstyle displaystyle="true"><mn>81</mn></mstyle></math> as <math><mstyle displaystyle="true"><msup><mrow><mn>9</mn></mrow><mrow><mn>2</mn></mrow></msup></mstyle></math> .

Since both terms are perfect squares, factor using the difference of squares formula, <math><mstyle displaystyle="true"><msup><mrow><mi>a</mi></mrow><mrow><mn>2</mn></mrow></msup><mo>-</mo><msup><mrow><mi>b</mi></mrow><mrow><mn>2</mn></mrow></msup><mo>=</mo><mrow><mo>(</mo><mi>a</mi><mo>+</mo><mi>b</mi><mo>)</mo></mrow><mrow><mo>(</mo><mi>a</mi><mo>-</mo><mi>b</mi><mo>)</mo></mrow></mstyle></math> where <math><mstyle displaystyle="true"><mi>a</mi><mo>=</mo><mn>4</mn><msup><mrow><mi>x</mi></mrow><mrow><mn>2</mn></mrow></msup></mstyle></math> and <math><mstyle displaystyle="true"><mi>b</mi><mo>=</mo><mn>9</mn></mstyle></math> .

Rewrite <math><mstyle displaystyle="true"><mn>4</mn><msup><mrow><mi>x</mi></mrow><mrow><mn>2</mn></mrow></msup></mstyle></math> as <math><mstyle displaystyle="true"><msup><mrow><mo>(</mo><mn>2</mn><mi>x</mi><mo>)</mo></mrow><mrow><mn>2</mn></mrow></msup></mstyle></math> .

Rewrite <math><mstyle displaystyle="true"><mn>9</mn></mstyle></math> as <math><mstyle displaystyle="true"><msup><mrow><mn>3</mn></mrow><mrow><mn>2</mn></mrow></msup></mstyle></math> .

Factor.

Since both terms are perfect squares, factor using the difference of squares formula, <math><mstyle displaystyle="true"><msup><mrow><mi>a</mi></mrow><mrow><mn>2</mn></mrow></msup><mo>-</mo><msup><mrow><mi>b</mi></mrow><mrow><mn>2</mn></mrow></msup><mo>=</mo><mrow><mo>(</mo><mi>a</mi><mo>+</mo><mi>b</mi><mo>)</mo></mrow><mrow><mo>(</mo><mi>a</mi><mo>-</mo><mi>b</mi><mo>)</mo></mrow></mstyle></math> where <math><mstyle displaystyle="true"><mi>a</mi><mo>=</mo><mn>2</mn><mi>x</mi></mstyle></math> and <math><mstyle displaystyle="true"><mi>b</mi><mo>=</mo><mn>3</mn></mstyle></math> .

Remove unnecessary parentheses.

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